Table 3 Between-group comparison of activated and deactivated brain regions during task 1 in patients with essential tremor (ET) and during task 2 in healthy controls (HC).

From: Voxel-based morphometry and task functional magnetic resonance imaging in essential tremor: evidence for a disrupted brain network

ROI

Voxels

MAX Z-statistic

MAX X (mm)

MAX Y (mm)

MAX Z (mm)

ACTIVATIONS

TASK 1 ET > TASK 2 HC

FP.l

537

8.29

60

91

43

TP.r/MTG.r

419

6.4

19

60

23

FP.r/MFG.r

257

7.55

32

88

31

PAC

219

5.49

51

85

35

PRG.l/MFG.l

101

7.68

61

60

62

TASK 1 ET < TASK 2 HC

CER.r/CER.l

6950

23.3

35

36

24

PRG.l/POG.l/LOC.l (sup)

4339

23.5

66

49

59

SMA

1569

10.8

43

54

64

PRG.r/POG.r/INS.r

975

9.88

13

65

45

LOC.r (sup)/SGp.r

529

10

22

34

63

Cau.r/THL.r

347

8.14

37

59

41

Cau.l/THL.l

295

7.92

48

57

41

Put.l/INS.l

140

7.85

63

62

37

FOC.r/IFG.r

245

7.97

28

78

38

FP.r

226

9.59

25

81

44

CGa.r/CGa.l

121

7.52

45

72

47

CN/CGp.r/CGp.l

105

7.06

45

21

45

DEACTIVATIONS

TASK 1 ET > TASK 2 HC

CER.r/CER.l

8734

− 17.9

55

33

23

POG.l/PRG.l/SMA/ LOC.l (sup/inf)/THL.l/ Put.l/Caud.l/OP.l

6053

− 22.7

67

49

59

POG.r/PRG.r/LOC.r (sup)/THL.r/ Caud.r

2014

− 13

33

45

70

INS.l

245

− 7.62

63

61

37

OP.r

188

− 8.67

34

19

45

LOC.r (inf)/TO3.r

149

− 11.4

24

40

30

INS.r/AMY.r

146

− 7.93

26

63

34

CGp.r/CGp.l

142

− 8.15

47

41

44

CGa.r/CGa.l

104

− 9.53

42

74

58

TASK 1 ET < TASK 2 HC

LOC.l (inf)/OP.l

177

− 13

49

19

34

OP.r

109

− 5.93

28

18

45

  1. Voxels, number of voxels in each significant cluster; MAX Z-statistic, value of the maximum z-statistic within the cluster; MAX X/Y/Z (mm), location of the maximum intensity voxel, given as spatial coordinate values in standard space (mm). For all clusters, the corresponding p values are FWE-corrected and < 0.05. For ease of reading, a cluster size of at least 100 voxels has been chosen for reporting the significant clusters derived from the statistical comparisons.
  2. AMY, amygdala; Caud, caudate; CER, cerebellum; CGa, anterior cingulate gyrus; CGp, posterior cingulate gyrus; CN, cuneal cortex; ET, patients with essential tremor; FOC, frontal orbital cortex; FP, frontal pole; FWE, family-wise error; HC, healthy controls; IFG, inferior frontal gyrus; inf, inferior; INS, insular cortex; l, left; LOC, lateral occipital cortex; MFG, middle frontal gyrus; MTG, middle temporal gyrus; OP, occipital pole; PAC, paracingulate gyrus; POG, postcentral gyrus; PRG, precentral gyrus; Put, putamen; r, right; ROI, region of interest; SGp, posterior supramarginal gyrus; sup, superior; SMA, supplementary motor areas; THL, thalamus; TO3, inferior temporal gyrus, temporooccipital part.
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