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Figure 1

From: Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal stem/progenitor cells

Figure 1

Age-dependent change of MCSP-positive cells in sun-protected and sun-exposed skin. Immunofluorescence staining of MCSP (green) and α6 integrin (red) in 30s sun-protected Caucasian skin (A), 60s sun-protected Caucasian skin (B), 30s sun-exposed Caucasian skin (C) and 60s sun-exposed Caucasian skin (D) [numbers indicate the age range (decade) of the skin donors]. MCSP-positive cell density was analyzed using WINROOF 2013 image analyzing software (Mitani, Fukui, Japan, https://www.mitani-visual.jp/products/image_analys_ismeasure-ment/winroof/) (E). mRNA expression level of MCSP was analyzed by qPCR (F). Bars: 100 μm. Data are expressed as mean ± SD of three independent experiments from each of 6 different donors in E and from each of 5 donors in F. *p < 0.05., ***p < 0.001.

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