Figure 5 | Scientific Reports

Figure 5

From: PD-L1 expression in bone marrow plasma cells as a biomarker to predict multiple myeloma prognosis: developing a nomogram-based prognostic model

Figure 5

Development of the prognostic nomogram. (A) A nomogram for estimating OS in the training (retrospective) cohort. (B) Calibration curves for predicting 1-year, 2-year, and 4-year OS were created by plotting the observed survival probabilities (y-axis) against the nomogram-predicted probabilities (x-axis). The vertical bars indicate the 95% CIs, which were calculated by bootstrapping with 1,000 resamples. The 45-degree line indicates an ideal model. (C) The Kaplan–Meier OS curves in the three risk groups according to the tertiles of the nomogram’s total score. (D) Time-dependent AUC analyses with 1,000 bootstrap replicates for evaluating the performance and prediction accuracy of the nomogram in the training cohort. (E) Calibration curves for 12-month OS in the validation (prospective) cohort, which were created by plotting the observed survival probabilities (y-axis) against the nomogram-predicted probabilities (x-axis). The 45-degree line indicates an ideal model. (F) The Kaplan–Meier OS curves in the validation cohort according to the nomogram. (G) The time-dependent AUC analyses in the validation cohort. AUC area under the curve, OS overall survival, CI confidence interval, PFS progression-free survival.

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