Figure 1

Isolated effects fitting to clinical data. In these plots the solid line represents the isolated effects functions (a) \(M^I_{PGU}\), (b) \(M^G_{HGP}\), (c) \(M^{I_\infty }_{HGP}\), and (d) \(M^{\Gamma _0}_{HGP}\) fitted to the clinical data from T2DM patients. Each symbol represents the mean measured value of the tissue/organ response to a local change on the solute concentration, from \(n_p\) subjects. For these metabolic rates, the fitting approach was static.