Figure 3
Prediction of inter-individual UV sensitivity from molecular data and identification of MED-correlated molecular phototypes: (a) Cross-validated predictions of MED from gene expression data using lasso regression models. (b) Cross-validated predictions of MED from DNA methylation data. (c) Cross-validated predictions of MED from combination of gene expression and DNA methylation data. (d) Fused similarity network generated from gene expression and DNA methylation data of irradiated samples, with nodes colored by molecular phototypes identified through spectral clustering. (e) Distribution of MED stratified by the molecular phototypes identified through spectral clustering on the fused similarity network. Statistical comparison was performed using unpaired two-sided t-tests. Plots were generated using R v3.6.176 software.
