Figure 4
Molecular subtyping identifies heterogeneous biological responses to irradiation that correlate with innate UV sensitivity: (a) Heatmap showing the predictivity of the most defining pathways for each of the molecular phototypes to UV irradiation. The heatmap is scaled by pathway to enhance readability, average predictivity of a given pathway over all three molecular phototypes is shown to the left of the heatmap in original scale. (b) Extent of DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) measured in the molecular phototypes 24 h after the last irradiation. Statistical comparison was performed using unpaired two-sided t-tests. Plots were generated using R v3.6.176 software.
