Figure 1 | Scientific Reports

Figure 1

From: The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission

Figure 1

The diversity and evolutionary relationships of nitric oxide synthases in animals and other eukaryotes. The representative lineages of deuterostomes, protostomes, and basal metazoans are highlighted. Unicellular eukaryotes and green algae are shown as outgroups. Names of the species are indicated in each case using the existing classification of NOSs (see text for details). For vertebrates, we marked different NOS to reflect their functional specification. nNOS—neuronal, which corresponds to human PDZ-containing NOS-1; iNOS—inducible or NOS-2; eNOS—endothelial or NOS-3. For placozoans, we indicated the haplotype (H1, H2, H4, H13)/species name and the number of NOS genes as referred to in the text (e.g., they correspond to Trichoplax NOS-1 [PDZ-domain containing], NOS-2 and NOS-3 respectively). All NOSs containing PDZ domains are indicated by asterisks. Phylogenetic trees were inferred using the Maximum Likelihood algorithm. The references for each particular gene and/or their sequences with relevant GeneBank accession numbers are summarized in the supplementary dataset (Excel Table).

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