Figure 5

Pearson correlations to assess the relationship between anxiety-like behaviour and the relative concentrations of (A) methionine, (B) malate, (C) serine, (D) malonate, (E) lysine, and (F) creatine in either kidney (A,B,C) or heart (D,E,F) tissues (Blue Cross, n = 9 control animals; Red Triangle, n = 14 stressed animals). There were negative correlations between the number of center squares entered and methionine (r = –0.66, p = 0.0007), malate (r = –0.64, p = 0.0011), and creatine (r = –0.52, p = 0.0114), indicating that a higher anxiety-like state was linked to higher methionine, malate, and creatine concentrations. There were positive correlations between the number of center squares entered and serine (r = 0.45, p = 0.0293), malonate (r = 0.57, p = 0.0050), and lysine (r = 0.49, p = 0.0173), indicating that a higher anxiety-like state was linked to lower serine, malonate, and lysine concentrations.