Table 2 Circulating white blood cells, neutrophil to lymphocyte ratio (NLR), H2O2 and risk of breast cancer.

From: Neutrophil to lymphocyte ratio and breast cancer risk: analysis by subtype and potential interactions

 

Cases/Controls

ORa

95% CI

ORb

95% CI

Neutrophils #, 103/μL

< 2.8

72/120

1.0

 

1.0

 

2.8–3.7

100/123

1.26

0.85–1.89

1.17

0.77–1.79

> 3.70

127/113

1.66

1.12–2.47

1.40

0.92–2.15

P-trend

  

0.002

 

0.02

Neutrophils %

 < 48.6

54/121

1.0

 

1.0

 

48.6–57

109/127

1.88

1.24–2.86

1.79

1.17–2.78

 > 57

136/111

2.42

1.60–3.68

2.14

1.39–3.32

P-trend

  

 < 0.001

 

 < 0.001

Monocytes #, 103/μL

 < 0.3

82/131

1.0

 

1.0

 

0.3–0.44

114/108

1.59

1.08–2.34

1.61

1.06–2.43

 > 0.44

103/117

1.43

0.97–2.11

1.36

0.90–2.07

P-trend

  

0.18

 

0.38

Monocytes %

 < 5.87

118/125

1.0

 

1.0

 

5.87–7

108/150

0.86

0.60–1.23

0.95

0.65–1.40

 > 7

73/84

1.02

0.68–1.54

1.06

0.68–1.64

P-trend

  

0.16

 

0.17

Lymphocytes #, 103/μL

 < 1.9

136/133

1.0

 

1.0

 

1.9–2.5

107/119

0.85

0.59–1.22

0.93

0.63–1.36

 > 2.5

56/104

0.52

0.34–0.78

0.54

0.35–0.83

P-trend

  

 < 0.001

 

0.001

Lymphocytes %

< 31

141/124

1.0

 

1.0

 

31–39

106/123

0.79

0.55–1.13

0.87

0.59–1.27

> 39

52/111

0.44

0.29–0.67

0.51

0.33–0.79

P-trend

  

 < 0.001

 

 < 0.001

NLR

 < 1.26

58/117

1.0

 

1.0

 

1.26–1.85

101/121

1.64

1.08–2.49

1.50

0.97–2.33

 > 1.85

139/117

2.19

1.46–3.30

1.93

1.26–2.97

P-trend

  

 < 0.001

 

 < 0.001

H2O2 #, ng/mL

< 284

78/52

1.0

 

1.0

 

284–517

29/48

0.42

0.23–0.75

0.42

0.22–0.79

> 517

19/49

0.25

0.13–0.47

0.26

0.13–0.51

P-trend

  

 < 0.001

 

 < 0.001

  1. aAdjusted for age at diagnosis (cases) and age at interview (controls).
  2. bFurther adjusted for age at menarche, parity, menopausal status, and BMI.