Figure 2
Alignment of the U5 region and downstream sequence of various HIV-1 subtypes and circulating recombinant forms. Nucleotide positions are relative to HXB2 (accession number K03455). Identity is indicated by dots; insertions/deletions are indicated by dashes. Several landmarks such as PAS (polyadenylation signal), PBS (Primer Binding Site), DIS (Dimer Initiation Signal), SD (major splice Donor Site), and PSI (Packaging Signal) motifs of the corresponding 5′ UTR sequence are depicted. Previously reported transcription factors are underlined11,12,14,27. Strain-specific variability is represented as hatched rectangles below the sequence; strain-specific transcription factors predicted and identified by gel shift are indicated as dash and solid rectangles, respectively.
