Figure 4
DIO rat platelets show platelet signalling alterations related to SFKs-mediated pathways. (A) 1D-Western blot analysis of Src-pTyr419 and Src pan protein expression levels in platelets from individual samples (13 lean-matched controls and 14 DIO rats). (B) Densitometry graphs showing the mean values ± SD of Src (Tyr 419) corrected by Src. Statistical analysis was done by unpaired t test (p = 0.06). (C) Densitometry graphs showing the mean values ± SD of Src (Tyr 419) corrected by Src in a subgroup of animals (extreme weight and high levels of glucose, 6 DIO and 6 controls). Statistical analysis was done by unpaired t test (p = 0.07). Images are representative of the results obtained and show samples distributed in one gel (Supplementary Fig. 2). IB immunoblot.
