Table 3 Correlations between metabolic intensity and oncogenic signaling pathways according to pathology.

From: Metabolic radiogenomics in lung cancer: associations between FDG PET image features and oncogenic signaling pathway alterations

Pathways

ADC

SQCC

SCLC

p value

FC

FDR

p value

FC

FDR

p value

FC

FDR

Cell cycle

Mutation

0.465

− 0.067

0.789

0.351

0.198

0.829

0.401

− 0.015

0.681

LOF

0.927

− 0.035

0.998

0.478

− 0.083

0.875

0.389

0.036

0.681

Fusion

         

CNV

0.382

− 0.059

0.789

0.911

0.012

0.964

0.631

− 0.057

0.773

Hippo

Mutation

0.239

0.007

0.763

0.038*

0.193

0.616

0.303

− 0.075

0.681

LOF

         

Fusion

         

CNV

         

Myc

Mutation

      

0.295

− 0.012

0.681

LOF

         

Fusion

         

CNV

0.951

− 0.075

0.998

   

0.031

0.132

0.596

Notch

Mutation

0.117

− 0.009

0.530

0.676

− 0.033

0.875

0.242

− 0.100

0.675

LOF

0.998

− 0.078

0.998

0.318

− 0.080

0.829

0.107

0.228

0.596

Fusion

         

CNV

   

0.292

− 0.136

0.829

0.718

− 0.023

0.789

Nrf2

Mutation

0.254

− 0.162

0.763

0.901

− 0.011

0.964

0.529

0.417

0.711

LOF

         

Fusion

         

CNV

0.504

− 0.061

0.789

0.899

− 0.012

0.964

   

PI3-Kinase

Mutation

0.034*

− 0.145

0.408

0.982

0.001

0.982

0.455

− 0.022

0.692

LOF

   

0.659

− 0.069

0.875

0.993

− 0.091

0.993

Fusion

         

CNV

0.434

− 0.014

0.789

0.195

0.113

0.805

0.168

0.146

0.596

RTK/RAS-Kinase

Mutation

0.329

− 0.137

0.789

0.083

0.170

0.724

0.180

0.252

0.596

LOF

         

Fusion

         

CNV

      

0.183

0.086

0.596

TGFβ

Mutation

< 0.001

0.101

0.001*

   

0.479

− 0.158

0.692

LOF

0.118

− 0.161

0.529

      

Fusion

         

CNV

      

0.634

− 0.045

0.773

p53

Mutation

0.072

0.119

0.529

0.113

0.135

0.724

0.473

− 0.069

0.692

LOF

0.469

− 0.027

0.789

0.281

− 0.106

0.829

0.142

0.199

0.596

Fusion

         

CNV

0.848

− 0.048

0.998

0.694

− 0.056

0.875

   

β-catenin/Wnt

Mutation

LOF

Fusion

CNV

0.953

− 0.059

0.998

0.581

− 0.067

0.875

0.709

0.198

0.789

0.643

− 0.022

0.626

      
      

0.831

− 0.055

0.876

  1. *Significant correlation; ADC, adenocarcinoma; SQCC, squamous cell carcinoma; SCLC, small cell lung cancer; FC, fold change; FDR, false discovery rate; LOF, loss of function; CNV, copy number variation.
Back to article page