Figure 1 | Scientific Reports

Figure 1

From: Identification of flux checkpoints in a metabolic pathway through white-box, grey-box and black-box modeling approaches

Figure 1

Second part of E. histolytica glycolysis pathway. The pathway is formed by 3-phosphoglycerate mutase (PGAM), enolase (ENO) and pyruvate phosphate dikinase (PPDK). Reduction of pyruvate to L-lactate (Lac) consuming NADH (dashed lines) is not part of the parasite pathway, but lactate dehydrogenase (LDH) was used in the in vitro reconstituted pathway in order to experimentally follow the final flux and establish a quasi steady-state to Lac 8. Metabolite action in enzyme inhibition is represented in red. 3PG 3-phosphoglycerate; 2PG 2-phosphoglycerate; PEP phosphoenolpyruvate; Pyr pyruvate.

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