Figure 6 | Scientific Reports

Figure 6

From: Identification of flux checkpoints in a metabolic pathway through white-box, grey-box and black-box modeling approaches

Figure 6

Flux and metabolite concentration predictions with COPASI model with an added adjustment term. (A) Flux predictions by the model when PPDK activity is varied. Dotted line: curve obtained with the best adjustment term (3,088,970). (B) PGAM (blue squares), ENO (yellow circles) and PPDK (red triangles) fluxes predicted as function of time. (C) 2PG (green), PEP (blue) and Pyr (yellow) concentration predictions. (D) Flux predicted by the model. RMSE = 1.71 nmol·min−1, MAE = 1.47 nmol·min−1, R2 = 0.98. Circle colors refer to the varied enzyme activity: PGAM (blue), ENO (yellow) or PPDK (red).

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