Table 5 List of the main properties of each model.

From: Identification of flux checkpoints in a metabolic pathway through white-box, grey-box and black-box modeling approaches

Modela

Name

Specificityb

Number of parameters

Based on…

0

Moreno-Sanchez model

See8

20

Experimental kinetic data

1

Adjusted Moreno-Sanchez model

Respects the experimental conditions at a pseudo steady-state

20

2

ANN model (NeuralNet, log, HU = 1)

Only uses the experimental dots

6

Enzyme activities and final flux data

3

ANN model (NeuralNet, tanh, HUs = 18)

Uses data from the fitting curves

91

4

UUBB model

Use of UUBB equation for PPDKc

29

Experimental and fitted kinetic data

5

UUBB model optimized

Uses the UUBB equation for PPDK with optimized parametersc

29

6

Model with an added adjustment term

PPDK equation with an added adjustment termc

21

Experimental kinetic data + adjustment term

  1. aOnly the best models from each approach are kept.
  2. bFor a complete description of the modeling process, see the “Methodology” section.
  3. cRespect of pseudo steady-state experimental conditions.
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