Figure 3 | Scientific Reports

Figure 3

From: Short and long-term evaluation of the impact of proton minibeam radiation therapy on motor, emotional and cognitive functions

Figure 3

Memory assessment. Similar mean distance travelled by both groups in the ORT (A) and OLT (C) at 48 h before irradiation and 1, 5, and 10 months post-irradiation (PI). Similar mean discrimination ratio for both groups in the ORT (B (time spent exploring the novel object – time spent exploring the familiar object)/time spent exploring both objects) and in the OLT (D (time spent exploring the novel location of the object – time spent exploring the familiar location)/time spent exploring both objects) at 48 h before irradiation and 1, 5, and 10 months PI. Similar mean distance travelled to find the platform across trials by both groups in the MWM test at 7 months PI (E). Similar mean distance travelled in each quadrant of the MWM by both groups during the probe test (F). Similar mean percentage of correct choices to find the east arm (G) and mean number of trials needed to reach the learning criterion (H) during the training sessions of the cross-maze test for both groups. The majority of animals showed a place strategy (east arm) rather than a response strategy (west arm) during the probe test, and there was no significant difference between the groups (I). The data are presented as the mean ± SEM; *p < 0.05.

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