Figure 1 | Scientific Reports

Figure 1

From: Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model

Figure 1

Schematic diagram of human tau isoforms used in the current study. Constructs of transgenic flies include WTFL, WT421, E14FL, E14D421A, E14421, APFL, APD421A, and AP421. WT: wild type; E14: 14 Ser/Thr sites as labeled, change to glutamic acids mimicking pseudo-phosphorylation as indicated by red bars. AP: the identical Ser/Thr residues as in E14 change to alanines mimicking non-phosphorylation as indicated by blue bars. FL: 1–441 residues; 421: 1–421 residues mimicking FL truncated at Asp421 site as indicated by the black column; D421A: Asp421 changes to alanine mimicking non-cleavage at Asp421 as indicated by the blue bars with black outlines; The different domains of tau are color-coded (orange: N terminal domain; yellow: the proline-rich domain; magenta: the microtubule-binding domain; green: C terminal domain).

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