Figure 3

Time dependence of ΔC/C₀ measured for E. coli U433 treated with different concentrations of (A) amikacin and (D) ampicillin. Positive control represents the data obtained from E. coli U 433 without antibiotics, and media represents the data of cell-free media. (ΔC/C₀) × d(ΔC/C₀)/dt numerically calculated for E. coli U433, which was treated with different concentrations of (B) amikacin and (E) ampicillin. The (ΔC/C₀) × d(ΔC/C₀)/dt curves are shifted to facilitate viewing. The area enclosed by the (ΔC/C₀) × d(ΔC/C₀)/dt curve and the X-axis, which is denoted by the shaded region in the inset of (C), normalized by the area of positive control (A_pc) (A/A_pc, black symbols) and similarity measures (purple symbols) estimated using the pattern matching algorithm for E. coli U433, which was treated with different concentrations of (C) amikacin and (F) ampicillin.