Figure 6 | Scientific Reports

Figure 6

From: Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists

Figure 6

In vitro activity profiles of corydine (1) and corydaline (2) to the human MOR. (a) Concentration-dependent inhibition of [3H]DAMGO binding to CHO-hMOR cell membranes was determined in the competitive radioligand binding assay. (b) Agonist activities of test compounds to the MOR as stimulation of [35S]GTPγS binding were determined in the [35S]GTPγS binding assay with CHO-hMOR cell membranes. (c) β-Arrestin2 recruitment activities of test compounds to the MOR were determined in the PathHunter β-arrestin2 assay. Values are means ± SEM (n = 3–4 independent experiments performed in duplicate).

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