Table 2 In vitro binding affinities of corydine (1) and corydaline (2) to the MOR.

From: Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists

Compound

Ki (µM)a

Corydine (1)

2.82 ± 0.61*

Corydaline (2)

1.23 ± 0.29

Morphine

0.0067 ± 0.0009

  1. aDetermined in competitive radioligand binding assays using CHO-hMOR cell membranes. Inhibitory constant (Ki) values were calculated from the competition binding curves by nonlinear regression analysis. Morphine was used as reference MOR ligand. Values are means ± SEM (n = 3–4 independent experiments performed in duplicate). *P < 0.05 for corydine (1) vs. corydaline (2) (unpaired t-test).
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