Figure 3 | Scientific Reports

Figure 3

From: Functional skeletal muscle model derived from SOD1-mutant ALS patient iPSCs recapitulates hallmarks of disease progression

Figure 3

Phenotypic myotube characterization. Myotubes stained for MyHC, nAChR and DAPI, depicting diffuse to no AchR clusters in SOD1-mutant cultures. Yellow arrows point to nAChR clusters on SOD1 myotubes. Nuclei staining (DAPI) showing decreased fusion in myotube cultures, as evidenced by MyHC−/DAPI+ unfused myoblasts in the background. Imaged with Volocity software, version 6.3.0 (PerkinElmer). Scale bar = 50 μm.

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