Figure 9 | Scientific Reports

Figure 9

From: Transcriptomic determinants of the response of ST-111 Pseudomonas aeruginosa AG1 to ciprofloxacin identified by a top-down systems biology approach

Figure 9

Conceptualization of effects of ciprofloxacin treatment in PaeAG1 at the molecular level. Effects of DNA damage triggers RecA increment, which cleaves different repressors such as LexA, inducing the SOS response, but also phages induction repressors, and other elements. The general stress induces the RpoS response, modulating different responses and virulence factors. Other modulators induce changes in the metabolic state of cells, expression of virulence factors, as well as the down-shift in ribosomal activity. Together, all changes imply modulation of multiple responses with pleiotropic effects at a molecular level and regulation of phenotypes to face the stress given by the antibiotic.

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