Table 3 Pathways related to DEGs network of PaeAG1 exposed to ciprofloxacin, according to KEGG annotation.
KEGG term ID | Term description | Total gene count | DEGs 2.5 h | DEGs 5 h | Modules | Regulation (% DEGs)* | ||
|---|---|---|---|---|---|---|---|---|
Observed gene count | FDR | Observed gene count | FDR | |||||
paeb01130 | Biosynthesis of antibiotics | 266 | 30 | 0.0015 | 34 | 0.00047 | Brown, Yellow | Down (61%) |
paeb01110 | Biosynthesis of secondary metabolites | 320 | 30 | 0.0352 | 31 | 0.0205 | Yellow | Down (70%) |
paeb00650 | Butanoate metabolism | 37 | 8 | 0.0133 | 9 | 0.0068 | Yellow | Down (55%) |
paeb01200 | Carbon metabolism | 126 | 15 | 0.0258 | 18 | 0.0068 | Yellow | Down (80%) |
paeb00020 | Citrate cycle (TCA cycle) | 30 | 7 | 0.0158 | 8 | 0.0068 | Yellow | Down (75%) |
paeb00061 | Fatty acid biosynthesis | 27 | 7 | 0.0131 | 9 | 0.0014 | Yellow | Down (100%) |
paeb01212 | Fatty acid metabolism | 49 | 8 | 0.0309 | 10 | 0.0068 | Yellow | Down (90%) |
paeb00405 | Phenazine biosynthesis | 20 | 5 | 0.0309 | 6 | 0.0127 | Brown | Up (100%) |
paeb00640 | Propanoate metabolism | 47 | 12 | 0.00061 | 16 | 3.87e-06 | Brown, Yellow | Variable (50/50) |
paeb03060 | Protein export | 15 | 5 | 0.026 | 3 | 0.0014 | Yellow | Down (100%) |
paeb02024 | Quorum sensing | 86 | 11 | 0.0317 | 14 | 0.0068 | Brown | Up (69%) |
paeb03010 | Ribosome | 55 | 27 | 1.95e-14 | 27 | 2.63e-13 | Blue | Down (100%) |
paeb03018 | RNA degradation | 17 | 5 | 0.0258 | 5 | 0.0273 | Blue | Down (60%) |
paeb00072 | Synthesis and degradation of ketone bodies | 10 | 4 | 0.0258 | 4 | 0.0273 | Brown, Turquoise | Up (100%) |
paeb00280 | Valine, leucine and isoleucine degradation | 46 | 11 | 0.0015 | 11 | 0.0023 | Brown, Turquoise | Up (82%) |
