Figure 4 | Scientific Reports

Figure 4

From: Testing the impact of a single nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor on experimental cerebral malaria in mice

Figure 4

Mutating the ApiAP2 TF of PbANKA to ApiAP2 of PbNK65 does not alter its ECM inducing ability. (A, B) Mice were infected with 106 iRBC/mouse dose of mutant PbANKAS and WT PbANKAF parasites microanatomic changes showing dark colored hemorrhagic areas in Evans blue stained brains (A) and histologic changes showing hemorrhagic areas (black arrow heads) and RBC congested capillaries (green arrow heads) in hematoxylin and Eosin stained brain sections are shown (B). (C, D) Two different inoculation doses were used to infect mice and changes in parasitemia (C) and survival (D) are graphed. Each circle represents a single mouse and line represents mean for (C) Data is representative of two independent experiments.

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