Table 1 Proteins that were significantly altered in bvFTD compared to controls.

From: Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation

Protein

Symbol

Uniprot code

LogFC

P-value

Increased

Complement C3

C3

P01024

0.59

0.0016

Cathepsin H

CTSH

P09668

17.19

0.0016

Myosin-2

MYH2

Q9UKX2

4.50

0.0033

Sushi domain-containing protein 5

SUSD5

O60279

11.93

0.0117

Eukaryotic translation initiation factor 5A

EIF5A

P63241

3.01

0.0230

Protein S100A-8

S100A8

P05109

0.87

0.0230

Apolipoprotein L1

APOL1

O14791

0.59

0.0401

WD repeat-containing protein 1

WDR1

O75083

5.94

0.0422

Decreased

Cartilage acidic protein 1

CRTAC1

Q9NQ79

0.64

0.0024

Fibulin-1

FBLN1

P23142

0.59

0.0024

Complement C1S

C1S

P09871

0.38

0.0033

EGF-containing fibulin-like extracellular matrix protein 1

EFEMP1

Q12805

0.62

0.0067

Gelsolin

GSN

P06396

0.40

0.0069

Sex hormone-binding globulin

SHBG

P04278

0.69

0.0074

Inter-alpha-trypsin inhibitor heavy chain H2

ITIH2

P19823

0.45

0.0074

Cartilage intermediate layer protein 2

CILP2

Q8IUL8

6.47

0.0099

Cartilage oligomeric matrix protein

COMP

P49747

0.42

0.0118

Perlecan

HSPG2

P98160

0.37

0.0242

Uromodulin

UMOD

P07911

0.66

0.0259

Complement C7

C7

P10643

0.41

0.0259

Vasorin

VASN

Q6EMK4

0.48

0.0259

Vitamin K-dependent Protein S

PROS1

P07225

0.29

0.0345

Immunoglobulin heavy variable 1–2

IGHV1

A0A0G2JMI3

2.63

0.0422

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