Table 3 Risk of hip fracture according to cumulative dose of PPI.

From: Proton pump inhibitor use and risk of hip fracture in patients with type 2 diabetes

PPI use

N

Fracture no

Crude HR (95% CI)

P value

Adjust HR (95% CI)

P value

Non-user (< 28 DDD)

177,364

1808 (1.02%)

1 (Ref.)

 

1 (Ref.)

 

28–65 DDD

14,985

222 (1.48%)

1.49 (1.29–1.71)

< 0.001

1.46 (1.27–1.68)

< 0.001

66–124 DDD

14,608

218 (1.49%)

1.46 (1.27–1.68)

< 0.001

1.39 (1.21–1.60)

< 0.001

> 125DDD

14,748

243 (1.65%)

1.60 (1.40–1.83)

< 0.001

1.39 (1.21–1.59)

< 0.001

  1. 95% CI 95% confidence interval, HR relative hazard ratio, Ref. reference, DDD defined daily dose, PPI proton pump inhibitors.
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