Table 3 Differences between sex in the Down syndrome group.
From: Evaluation of biochemical and hematological parameters in adults with Down syndrome
Variable | Female | Male | p-value (categorical) | p-value (continuous) | ||||
|---|---|---|---|---|---|---|---|---|
n | n OOR (%) | Median (P25–P75) | n | n OOR (%) | Median (P25–P75) | |||
Biochemical parameters | ||||||||
TSH (mUI/L) | 115 | 24 (20.9) | 2.79 (1.67–4.15) | 132 | 22 (16.7) | 2.85 (1.68–3.81) | 0.417 | 0.877 |
Na+ (mmol/L) | 116 | 1 (0.9) | 140.0 (139.0–141.0) | 132 | 3 (2.3) | 140.0 (139.0–141.0) | 0.625 | 0.277 |
K+ (mmol/L) | 113 | 1 (0.9) | 4.3 (4.2–4.5) | 132 | 0 (0.0) | 4.3 (4.1–4.6) | 0.461 | 0.871 |
Glucose (mmol/L) | 116 | 4 (3.4) | 4.9 (4.6–5.2) | 132 | 13 (9.8) | 5.1 (4.8–5.4) | 0.075 | 0.023 |
Urea (mmol/L) | 116 | 29 (25.0) | 6.2 (5.2–7.2) | 132 | 33 (25.0) | 6.0 (5.4–7.2) | 1.000 | 0.861 |
Creatinine (µmol/L) | 116 | 13 (11.2) | 68.0 (62.0–75.0) | 132 | 11 (8.3) | 82.0 (73.0–94.0) | 0.521 | < 0.001 |
eGFR (ml/min/1.73) | 116 | 4 (3.4) | 90.0 (83.1–90.0) | 132 | 5 (3.8) | 90.0 (87.0–90.0) | 1.000 | 0.179 |
Total bilirrubin (µmol/L) | 111 | 9 (8.1) | 9.0 (6.0–11.0) | 123 | 21 (17.1) | 10.0 (8.0–14.0) | 0.050 | < 0.001 |
TG (mmol/L) | 116 | 6 (5.2) | 0.82 (0.70–0.95) | 132 | 13 (9.8) | 0.92 (0.72–1.21) | 0.232 | 0.004 |
Total cholesterol (mmol/L) | 116 | 9 (7.8) | 4.9 (4.5–5.4) | 132 | 6 (4.5) | 4.9 (4.2–5.3) | 0.302 | 0.315 |
AST (U/L) | 113 | 8 (7.1) | 22.0 (18.0–26.0) | 132 | 4 (3.0) | 21.0 (19.0–25.0) | 0.234 | 0.754 |
ALT (U/L) | 116 | 13 (11.2) | 18.0 (14.0–25.0) | 132 | 12 (9.1) | 23.0 (16.0–29.0) | 0.674 | 0.002 |
AF (U/L) | 115 | 10 (8.7) | 76.0 (65.0–88.0) | 132 | 4 (3.0) | 76.5 (64.0–87.0) | 0.095 | 0.620 |
GGT (U/L) | 116 | 9 (7.8) | 16.0 (12.0–22.0) | 132 | 11 (8.3) | 19.0 (15.0–27.8) | 1.000 | 0.001 |
Total proteins (g/L) | 110 | 16 (14.5) | 68.5 (65.3–71.4) | 123 | 8 (6.5) | 68.5 (66.0–70.9) | 0.053 | 0.856 |
B12 (pmol/L) | 112 | 1 (0.9) | 292.0 (227.3–366.5) | 130 | 9 (6.9) | 286.5 (208.0–339.5) | 0.022 | 0.278 |
Folate (nmol/L) | 113 | 7 (6.2) | 13.9 (9.9–20.6) | 130 | 9 (6.9) | 11.6 (8.8–16.8) | 1.000 | 0.003 |
Hematological parameters | ||||||||
Hemoglobin (g/L) | 116 | 18 (15.5) | 139.0 (132.0–145.0) | 132 | 14 (10.6) | 152.0 (143.0–160.0) | 0.262 | < 0.001 |
Hematocrit (L/L) | 116 | 10 (8.6) | 0.42 (0.39–0.43) | 132 | 13 (9.8) | 0.45 (0.42–0.47) | 0.828 | < 0.001 |
RBC (× 1012/L) | 116 | 17 (14.7) | 4.3 (4.1–4.6) | 132 | 41 (31.1) | 4.7 (4.4–5.0) | 0.003 | < 0.001 |
MCV (fL) | 116 | 37 (31.9) | 96.2 (93.0–98.6) | 132 | 23 (17.4) | 94.6 (91.8–97.0) | 0.011 | 0.004 |
ESR (mm/h) | 81 | 75 (92.6) | 32.0 (21.5–47.5) | 98 | 62 (63.3) | 14.5 (7.0–30.5) | < 0.001 | < 0.001 |
MCHC (g/L) | 116 | 12 (10.3) | 334.0 (329.3–341.0) | 132 | 5 (3.8) | 338.5 (332.0–346.0) | 0.047 | 0.003 |
MCH (pg) | 116 | 71 (61.2) | 32.4 (30.9–33.3) | 132 | 66 (50.0) | 32.1 (31.0–32.7) | 0.096 | 0.189 |
RDW (%) | 116 | 18 (15.5) | 13.9 (13.4–14.6) | 132 | 12 (9.1) | 13.6 (13.1–14.3) | 0.171 | 0.016 |
Platelet count (× 109/L) | 116 | 3 (2.6) | 240.0 (216.0–289.0) | 132 | 6 (4.5) | 232.0 (196.0–260.8) | 0.508 | 0.024 |
MPV (fL) | 116 | 3 (2.6) | 7.9 (7.5–8.4) | 132 | 15 (11.4) | 7.8 (7.3–8.3) | 0.012 | 0.040 |
WBC (× 109/L) | 116 | 19 (16.4) | 5.1 (4.2–6.0) | 132 | 11 (8.3) | 5.5 (4.5–6.7) | 0.078 | 0.028 |
