Figure 2

Homozygous Snx14 mutation causes embryonic lethality in mice. (A) Viable Snx14^KO/KO embryos are not detected at Mendelian ratios at E10.5 and no Snx14^KO/KO mice were found at P0. (B) Snx14^KO/KO weighed less than their Snx14^WT/WT and Snx14^WT/KO littermates. Bars = Mean ± SD, *p < 0.05, **p < 0.01, one-way ANOVA. (C) Snx14^KO/KO embryos appear smaller, without clear vascularisation in the head (insets). (D) Surface visualisation of Snx14^WT/WT and Snx14^KO/KO embryos with optical projection tomography. (E) Internal visualisation of Snx14^WT/WT and Snx14^KO/KO embryos with high resolution episcopic microscopy (HREM).