Figure 3 | Scientific Reports

Figure 3

From: Proteins involved in the endoplasmic reticulum stress are modulated in synovitis of osteoarthritis, chronic pyrophosphate arthropathy and rheumatoid arthritis, and correlate with the histological inflammatory score

Figure 3

ER stress proteins detected in the inflamed synovial membrane: (A) DAVID analysis performed on the 51 proteins highlighted for their significant correlation to the histological inflammatory score, for their functional classifications. The pathway entitled “protein processing in endoplasmic reticulum (ER)” was selected. (B) Proteins involved in the ER pathway according to DAVID analysis. (C) STRING protein–protein interaction among the 51 proteins highlighted in Table 2. Red writings indicate proteins involved in the ER network according to DAVID analysis. (D) Correlation parameters between the 11 proteins involved in the ER according to DAVID. (E) Negative correlation between HSPA1A and TXNDC5 protein levels.

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