Table 3 Correlation parameters between S100A8/S100A9 and the 49 protein intensities correlated to the histological inflammatory score.

From: Proteins involved in the endoplasmic reticulum stress are modulated in synovitis of osteoarthritis, chronic pyrophosphate arthropathy and rheumatoid arthritis, and correlate with the histological inflammatory score

 

S100A8

S100A9

Pearson r

P value

Pearson r

P value

Protein S100A8/A9

0.9545

***

0.9545

***

Neutrophil defensin

0.9131

***

0.8637

***

Lymphocyte-specific protein 1

0.8527

***

0.8197

***

Coronin-1A

0.8417

***

0.8041

***

Plastin-2

0.837

***

0.8021

***

Cathepsin Z

0.8266

***

0.7937

***

Myeloid cell nuclear differentiation antigen

0.8118

***

0.7771

***

Tapasin

0.7384

***

0.6698

**

Profilin-1

0.7348

***

0.6748

***

Mesencephalic astrocyte-derived neurotrophic factor

0.7223

***

0.7417

***

Cathepsin S

0.7125

***

0.6177

**

Receptor-type tyrosine-protein phosphatase C

0.707

***

0.643

***

Rho GDP-dissociation inhibitor 2

0.6958

***

0.6217

**

Calreticulin

0.68

***

0.6088

**

Cytosol aminopeptidase

0.679

***

0.6264

**

Marginal zone B- and B1-cell-specific protein

0.667

**

0.7098

**

Elongation factor 1-gamma

0.6522

***

0.5827

**

Lamin-B1

0.6505

***

0.587

**

Echinoderm microtubule-associated protein-like 4

0.6346

**

0.5933

**

Phosphomannomutase 2

0.614

**

0.6091

**

Endoplasmic reticulum resident protein 29

0.5962

**

0.644

***

Peroxiredoxin-4

0.578

**

0.5787

**

Protein canopy homolog 2

0.5758

**

0.6744

***

Signal transducer and activator of transcription 1-alpha/beta

0.5704

**

0.5427

**

DnaJ homolog subfamily B member 11

0.5504

**

0.5635

**

Interferon-induced guanylate-binding protein 1

0.5373

**

0.566

**

Hypoxia up-regulated protein 1 (GRP170)

0.5357

**

0.5298

**

78 kDa glucose-regulated protein (GRP78) or BiP

0.5233

**

0.5043

*

Endoplasmin

0.5164

**

0.4804

*

Isocitrate dehydrogenase [NADP], mitochondrial

0.5118

*

0.4164

*

Protein disulfide-isomerase A4

0.5076

*

0.4499

*

Protein ERGIC-53

0.4971

*

0.4479

*

Tubulin alpha-4A chain

0.4941

*

0.4951

*

Neutral alpha-glucosidase AB

0.483

*

0.396

ns

Guanine nucleotide-binding protein subunit beta-2-like

0.4502

*

0.3353

ns

Signal recognition particle subunit SRP72

0.4444

*

0.4308

*

Thioredoxin domain-containing protein 5

0.4049

*

0.4182

*

Poly [ADP-ribose] polymerase 1

0.3561

ns

0.2772

ns

Cartilage acidic protein 1

− 0.3355

ns

− 0.3434

ns

Heat shock 70 kDa protein 1A/1B (HSP70-1)

− 0.5366

**

− 0.5838

**

LEM domain-containing protein 2

− 0.6254

**

− 0.5722

**

Nesprin-3

− 0.6296

**

− 0.6015

**

Tenascin-X

− 0.6321

**

− 0.5679

**

Spectrin beta chain, non-eryththrocytic 1

− 0.6884

***

− 0.6734

***

Scavenger receptor class A member 5

− 0.7069

**

− 0.6619

**

Carboxypeptidase Q

− 0.7156

***

− 0.7019

**

Lamin-B2

− 0.7414

***

− 0.7293

***

Glutathione peroxidase 3

− 0.7475

***

− 0.7667

***

Beta-2-syntrophin

− 0.7522

***

− 0.8171

***

Creatine kinase B-type

− 0.7555

***

− 0.7136

***

  1. Alarmins S100A8 and S100A9 were both correlated to the 50 other protein intensities obtained by MS/MS and correlated to the histological inflammatory score. r = coefficient correlation (Pearson test). *, **, *** Represent P-values < 0.05; 0.01 and 0.001, respectively.
  2. ns not significant.