Figure 3

Overall structure of GETV macro domain. (A) Cartoon representation of GETV macro domain with APD-ribose depicted as seen in the GETV macro domain ADP-ribose complex “pose 1”. β-sheets are coloured in slate, α-helices in teal and loops in pink. Secondary structure elements and the N- and C-termini are labelled. ADP-ribose is represented in stick-mode, with carbon atoms coloured in grey, oxygens in red, nitrogen atoms in blue and phosphorus atoms in orange. (B) Overlap of GETV macro domain, same colour coding as in (A), with the structures of CHIKV macro domain (3GPO) in red, VEEV macro domain (3GQ) in yellow and the SARS macro domain (2FAV) in grey. The N-termini, important loops and α-helices are labelled in black and violet for the GETV macro domain and in grey for SARS macro domain. For clarity, only the first β-strand is labelled. APD-ribose as observed in the GETV macro domain ADP-ribose complex “pose 1” and colour-coded as in (A) has been added for reference.