Figure 6
From: Decoding mitochondrial heterogeneity in single muscle fibres by imaging mass cytometry
Muscle fibres in patients with mtDNA encoded tRNA variants typically fall into two distinct populations for NDUFB8 levels. 2Dmito plots comparing oxidative phosphorylation targets against VDAC1. (A) P05 with a mutation in m.3243 A>G, (B) P06 with a mutation in m.3243A>G, (C) P07 with a mutation in m.3243A>G, (D) P08 with a point mutation in mitochondrial-encoded tRNA (m.10010T>C MT-TG), (E) P09 with a point mutation in mitochondrial-encoded tRNA (m.14709T>C MT-TE) and (F) P10 with a point mutation in mitochondrial-encoded tRNA (m.5543T>C MT-TW). Individual single-cell IMC measurement from each patient is represented by a coloured point in each panel. Control observations are in grey. Points representing patient fibres are coloured for by theta NDUFB8 for that fibre. Regression through the control data is drawn as a solid grey line and the 95% predictive interval for control fibres lies between the dashed grey lines. Total number of fibres above and below the control predictive interval are written above each panel.
