Figure 2
From: Human transcription factor and protein kinase gene fusions in human cancer
Clinical characterization of protein producing oncofusions by cancer stage. (A) The most common protein producing gene pairs in oncofusions. In total, protein producing fusions were comprised of 23,354 unique gene pairs predicted to produce one or more unique protein products. The most common pair was RPS6KB1-VMP1, with over 10 unique proteins, followed by ITGB6-RBMS2 and ALK-EML4 with 7 each, and LYRM9-P3H4 and RUNX1-RUNX1T1 at 5. Kinase and TF fusions were common in top protein producing gene pairs, illustrated by blue shading for the presence of a protein kinase in gene pair, red for TF, and orange for both. (B) Sunburst diagram of project and stage distribution of PK/TF oncofusions. The innermost layer represents the number of fusions in each project. The layers radiating out are the proportion of fusions detected in Stage I, II, III, and IV samples, in order from in to out. Total numbers of fusions from each stage is marked under the stage indicators.
