Figure 3

Domain analysis of protein producing fusions. (A) Intact, full-length domains identified in unique protein producing fusions. In total, 10,100 intact domains were detected. The protein tyrosine kinase domain was the most prevalent with 159 identifications. In addition, protein kinase domain was detected with 108 copies each. Kinase or TF specific domains included 44 and 131 unique domains, respectively. 455 copies of kinase-specific domains were seen, and 622 of TF specific. Kinase domains focused more on the two top kinase domains, whereas TF domains were a much more evenly distributed group, the top TF-specific domain, C2H2 type zinc finger, having 59 copies. (B) The number of domains per protein coding oncofusion in the TCGA projects. (C) Most common interactors of protein kinase/TF fusions. Y-axis describes numbers of unique protein producing fusions, where one or both of the fusion partner WT genes interact with the protein. Top right inset: Proportion of interactors found in COSMIC cancer gene census is higher in both protein kinase and transcription factor fusions, and most common in fusions between protein kinase and transcription factor genes.