Figure 4
From: Human transcription factor and protein kinase gene fusions in human cancer
Functional potential of Kinase/TF fusion interactors. (A) Interactors mapped to Reactome pathways. The interactors produced hits in almost 2000 pathways. Most prominent hits were centered around signal transduction pathways, which links to transcription events via TGF-β signaling pathway. The size of the node is directly proportional to number of fusions with interactors identified with the annotation from Reactome database. The used annotation file contained annotations for all levels of Reactome hierarchy. Included in the figure are pathways up to 7 steps away from the signal transduction root node. The node size is directly proportional to the sum of oncofusion interactors, and the count of fusions that interact with them. (B) Relative frequency of each pathway per TCGA project on a scale from 0 to 1 (1 being the pathway with most interactors). While pathways with the most potential interactors of fusions identified are the same in majority of the projects, different subpathways are seen in different projects, such as oncogenic MAPK signaling in DLBC and KIRP, or PI3-Akt signaling in UCS and CHOL.
