Figure 6
Gfap-hM3Dq mice lacking A1R, but not those lacking A2AR failed to exhibit CNO-induced analgesia. CNO-induced analgesia was observed in A1 heterozygous (Het) but not in A1 knockout (KO) mice in both CFA-injected (A) and saline-injected (B) hind paws (N = 9 A1 Het mice, and N = 13 A1 KO mice). CNO-induced analgesia remained intact in both A2A heterozygous and in A2A knockout mice in both the CFA-injected (C) and saline-injected (D) hind paws (N = 7 per group). +p < 0.01 compared to baseline in heterozygous mice; #p < 0.01 compared to baseline in knockout mice. Figures were prepared using Graphpad Prism 7.04.
