Figure 3
From: Penicillin causes non-allergic anaphylaxis by activating the contact system
Penicillin contributes to anaphylaxis by activating the contact system in rodents. (A) Penicillin-induced hypothermia could be countered by icatibant in propranolol-pretreated mice (n = 8). **P < 0.01. (B) Penicillin induced a rapid and reversible drop in blood pressure in a BK-dependent manner (n = 6). The rats were pretreated with icatibant (200 μg/kg, i.v.) or normal saline (NS). Five minutes later, penicillin (1,250 KU/kg) was injected (i.v.) and the arterial blood pressure was measured in NS-pretreated (blue line) or icatibant-pretreated (orange line) rats. **P < 0.01 vs. icatibant + penicillin. (C) Typical tracing showing that penicillin induced a rapid and reversible drop in rat blood pressure. The rats were injected (i.v.) with NS or penicillin (1,250 KU/kg) and the arterial blood pressure was constantly monitored. (D) Penicillin significantly increased BK release in rat plasma. BK concentration was determined by a commercial ELISA kit. **P < 0.01 vs. NS.
