Figure 3
Up-states in WT circuits exhibit spatiotemporal structure. (A) Three Up-states from a WT circuit. The ‘Within shuffle’ procedure consists of shuffling cells (marked with white boxes) within each Up-state. The ‘Between shuffle’ procedure consists of shuffling between Up-states while maintaining cell identity. The similarity index is then calculated by determining the mean pairwise correlation between Up-states (see “Methods”). (B) A one-way ANOVA across the mean similarity index of the three groups revealed a significant effect (F2,15 = 23.85, p < 10–4). Group WT mean similarity index of Up-states (0.83 ± 0.03; n = 6, black, most to the left group) is significantly higher than the mean similarity index of within shuffled Up-states (0.41 ± 0.05; t-test, p < 0.0001, red, middle group) and between shuffled Up-states (0.62 ± 0.03; t-test, p = 0.001, blue, most to the right group).
