Figure 4

Spatiotemporal patterns of Up-states of Fmr1^−/y circuits are more variable. (A) Heat maps of eight concatenated Up-states from a Fmr1^+/y circuit. Triangles below heat maps represent the pairwise similarity index between all Up-states, and the overall mean of similarity indices is in black (0.81). (B) Twelve concatenated Up-states from a Fmr1^−/y circuit, and similarity indices (mean of 0.63). (C) Group mean similarity index of Up-states in Fmr1^+/y circuits (0.83 ± 0.03; n = 6) was significantly higher than mean similarity index of Up-states in Fmr1^−/y circuits (0.68 ± 0.01; n = 7; Mann–Whitney test, p = 0.001).