Table 5 DAVID-assisted antibody microarray kinomic analysis of KEGG pathways in OC cells exposed for 24 h to 40 µM G28UCM.
SKOV3 (% of Control > 150 or < 50) | OVCAR3 (% of Control > 150 or < 50) | Both | Single |
|---|---|---|---|
KEGG pathways | KEGG pathways | ||
hsa04010:MAPK signaling pathway | hsa04010:MAPK signaling pathway | 1 | |
hsa04012:ErbB signaling pathway | hsa04012:ErbB signaling pathway | 1 | |
hsa04014:Ras signaling pathway | hsa04014:Ras signaling pathway | 1 | |
hsa04015:Rap1 signaling pathway | hsa04015:Rap1 signaling pathway | 1 | |
hsa04020:Calcium signaling pathway | hsa04020:Calcium signaling pathway | 1 | |
hsa04022:cGMP-PKG signaling pathway | hsa04022:cGMP-PKG signaling pathway | 1 | |
hsa04024:cAMP signaling pathway | hsa04024:cAMP signaling pathway | 1 | |
hsa04064:NF-kappa B signaling pathway | hsa04064:NF-kappa B signaling pathway | 1 | |
hsa04066:HIF-1 signaling pathway | hsa04066:HIF-1 signaling pathway | 1 | |
hsa04068:FoxO signaling pathway | hsa04068:FoxO signaling pathway | 1 | |
hsa04070:Phosphatidylinositol signaling system | 1 | ||
hsa04071:Sphingolipid signaling pathway | hsa04071:Sphingolipid signaling pathway | 1 | |
hsa04150:mTOR signaling pathway | hsa04150:mTOR signaling pathway | 1 | |
hsa04151:PI3K-Akt signaling pathway | hsa04151:PI3K-Akt signaling pathway | 1 | |
hsa04152:AMPK signaling pathway | 1 | ||
hsa04310:Wnt signaling pathway | hsa04310:Wnt signaling pathway | 1 | |
hsa04350:TGF-beta signaling pathway | 1 | ||
hsa04370:VEGF signaling pathway | hsa04370:VEGF signaling pathway | 1 | |
hsa04630:Jak-STAT signaling pathway | 1 | ||
hsa04668:TNF signaling pathway | hsa04668:TNF signaling pathway | 1 | |
hsa04910:Insulin signaling pathway | hsa04910:Insulin signaling pathway | 1 | |
hsa04912:GnRH signaling pathway | hsa04912:GnRH signaling pathway | 1 | |
hsa04913:Ovarian steroidogenesis | 1 | ||
hsa04914:Progesterone-mediated oocyte maturation | hsa04914:Progesterone-mediated oocyte maturation | 1 | |
hsa04915:Estrogen signaling pathway | hsa04915:Estrogen signaling pathway | 1 | |
hsa04916:Melanogenesis | hsa04916:Melanogenesis | 1 | |
hsa04917:Prolactin signaling pathway | hsa04917:Prolactin signaling pathway | 1 | |
hsa04919:Thyroid hormone signaling pathway | hsa04919:Thyroid hormone signaling pathway | 1 | |
hsa04920:Adipocytokine signaling pathway | hsa04920:Adipocytokine signaling pathway | 1 | |
hsa04921:Oxytocin signaling pathway | hsa04921:Oxytocin signaling pathway | 1 | |
hsa04922:Glucagon signaling pathway | 1 | ||
hsa04923:Regulation of lipolysis in adipocytes | 1 | ||
hsa04925:Aldosterone synthesis and secretion | 1 | ||
hsa04110:Cell cycle | hsa04110:Cell cycle | 1 | |
hsa04114:Oocyte meiosis | hsa04114:Oocyte meiosis | 1 | |
hsa04115:p53 signaling pathway | 1 | ||
hsa04144:Endocytosis | 1 | ||
hsa04510:Focal adhesion | hsa04510:Focal adhesion | 1 | |
hsa04520:Adherens junction | hsa04520:Adherens junction | 1 | |
hsa04540:Gap junction | hsa04540:Gap junction | 1 | |
hsa04550:Signaling pathways regulating pluripotency of stem cells | 1 | ||
hsa04810:Regulation of actin cytoskeleton | hsa04810:Regulation of actin cytoskeleton | 1 | |
hsa04261:Adrenergic signaling in cardiomyocytes | 1 | ||
hsa04270:Vascular smooth muscle contraction | hsa04270:Vascular smooth muscle contraction | 1 | |
hsa04320:Dorso-ventral axis formation | hsa04320:Dorso-ventral axis formation | 1 | |
hsa04360:Axon guidance | hsa04360:Axon guidance | 1 | |
hsa04380:Osteoclast differentiation | hsa04380:Osteoclast differentiation | 1 | |
hsa04960:Aldosterone-regulated sodium reabsorption | hsa04960:Aldosterone-regulated sodium reabsorption | 1 | |
hsa04961:Endocrine and other factor-regulated calcium reabsorption | 1 | ||
hsa04930:Type II diabetes mellitus | hsa04930:Type II diabetes mellitus | 1 | |
hsa04931:Insulin resistance | hsa04931:Insulin resistance | 1 | |
hsa04713:Circadian entrainment | 1 | ||
hsa04932:Non-alcoholic fatty liver disease (NAFLD) | 1 | ||
hsa04720:Long-term potentiation | hsa04720:Long-term potentiation | 1 | |
hsa04722:Neurotrophin signaling pathway | hsa04722:Neurotrophin signaling pathway | 1 | |
hsa04723:Retrograde endocannabinoid signaling | hsa04723:Retrograde endocannabinoid signaling | 1 | |
hsa04725:Cholinergic synapse | hsa04725:Cholinergic synapse | 1 | |
hsa04726:Serotonergic synapse | hsa04726:Serotonergic synapse | 1 | |
hsa04728:Dopaminergic synapse | 1 | ||
hsa04730:Long-term depression | hsa04730:Long-term depression | 1 | |
hsa04750:Inflammatory mediator regulation of TRP channels | hsa04750:Inflammatory mediator regulation of TRP channels | 1 | |
hsa05010:Alzheimer's disease | 1 | ||
hsa05014:Amyotrophic lateral sclerosis (ALS) | hsa05014:Amyotrophic lateral sclerosis (ALS) | 1 | |
hsa05020:Prion diseases | hsa05020:Prion diseases | 1 | |
hsa05030:Cocaine addiction | hsa05030:Cocaine addiction | 1 | |
hsa05031:Amphetamine addiction | 1 | ||
hsa05034:Alcoholism | 1 | ||
hsa05100:Bacterial invasion of epithelial cells | hsa05100:Bacterial invasion of epithelial cells | 1 | |
hsa05120:Epithelial cell signaling in Helicobacter pylori infection | hsa05120:Epithelial cell signaling in Helicobacter pylori infection | 1 | |
hsa05130:Pathogenic Escherichia coli infection | hsa05130:Pathogenic Escherichia coli infection | 1 | |
hsa05131:Shigellosis | hsa05131:Shigellosis | 1 | |
hsa05132:Salmonella infection | hsa05132:Salmonella infection | 1 | |
hsa05133:Pertussis | hsa05133:Pertussis | 1 | |
hsa05140:Leishmaniasis | hsa05140:Leishmaniasis | 1 | |
hsa05142:Chagas disease (American trypanosomiasis) | hsa05142:Chagas disease (American trypanosomiasis) | 1 | |
hsa05145:Toxoplasmosis | 1 | ||
hsa05146:Amoebiasis | 1 | ||
hsa05152:Tuberculosis | 1 | ||
hsa05160:Hepatitis C | hsa05160:Hepatitis C | 1 | |
hsa05161:Hepatitis B | hsa05161:Hepatitis B | 1 | |
hsa05162:Measles | hsa05162:Measles | 1 | |
hsa05164:Influenza A | hsa05164:Influenza A | 1 | |
hsa05166:HTLV-I infection | hsa05166:HTLV-I infection | 1 | |
hsa05168:Herpes simplex infection | hsa05168:Herpes simplex infection | 1 | |
hsa05169:Epstein-Barr virus infection | hsa05169:Epstein-Barr virus infection | 1 | |
hsa05416:Viral myocarditis | 1 | ||
hsa05200:Pathways in cancer | hsa05200:Pathways in cancer | 1 | |
hsa05202:Transcriptional misregulation in cancer | hsa05202:Transcriptional misregulation in cancer | 1 | |
hsa05203:Viral carcinogenesis | hsa05203:Viral carcinogenesis | 1 | |
hsa05205:Proteoglycans in cancer | hsa05205:Proteoglycans in cancer | 1 | |
hsa05206:MicroRNAs in cancer | hsa05206:MicroRNAs in cancer | 1 | |
hsa05210:Colorectal cancer | hsa05210:Colorectal cancer | 1 | |
hsa05211:Renal cell carcinoma | hsa05211:Renal cell carcinoma | 1 | |
hsa05212:Pancreatic cancer | hsa05212:Pancreatic cancer | 1 | |
hsa05213:Endometrial cancer | hsa05213:Endometrial cancer | 1 | |
hsa05214:Glioma | hsa05214:Glioma | 1 | |
hsa05215:Prostate cancer | hsa05215:Prostate cancer | 1 | |
hsa05216:Thyroid cancer | hsa05216:Thyroid cancer | 1 | |
hsa05218:Melanoma | hsa05218:Melanoma | 1 | |
hsa05219:Bladder cancer | hsa05219:Bladder cancer | 1 | |
hsa05220:Chronic myeloid leukemia | hsa05220:Chronic myeloid leukemia | 1 | |
hsa05221:Acute myeloid leukemia | hsa05221:Acute myeloid leukemia | 1 | |
hsa05222:Small cell lung cancer | hsa05222:Small cell lung cancer | 1 | |
hsa05223:Non-small cell lung cancer | hsa05223:Non-small cell lung cancer | 1 | |
hsa05230:Central carbon metabolism in cancer | hsa05230:Central carbon metabolism in cancer | 1 | |
hsa05231:Choline metabolism in cancer | hsa05231:Choline metabolism in cancer | 1 | |
hsa04062:Chemokine signaling pathway | hsa04062:Chemokine signaling pathway | 1 | |
hsa04611:Platelet activation | hsa04611:Platelet activation | 1 | |
hsa04620:Toll-like receptor signaling pathway | hsa04620:Toll-like receptor signaling pathway | 1 | |
hsa04621:NOD-like receptor signaling pathway | 1 | ||
hsa04622:RIG-I-like receptor signaling pathway | 1 | ||
hsa04650:Natural killer cell mediated cytotoxicity | hsa04650:Natural killer cell mediated cytotoxicity | 1 | |
hsa04660:T cell receptor signaling pathway | hsa04660:T cell receptor signaling pathway | 1 | |
hsa04662:B cell receptor signaling pathway | hsa04662:B cell receptor signaling pathway | 1 | |
hsa04664:Fc epsilon RI signaling pathway | hsa04664:Fc epsilon RI signaling pathway | 1 | |
hsa04666:Fc gamma R-mediated phagocytosis | hsa04666:Fc gamma R-mediated phagocytosis | 1 | |
hsa04670:Leukocyte transendothelial migration | hsa04670:Leukocyte transendothelial migration | 1 | |
Sum of affected KEGG pathways: 103 | Sum of affected KEGG pathways: 106 | 92 | 25 |
