Table 3 Area under the ROC curves, cut-off value, sensitivity, and specificity in CD and UC patients.

From: Serological cytokine signature in paediatric patients with inflammatory bowel disease impacts diagnosis

Cytokine

AUC

Sensitivity (%)

Specificity

Cut-off value (pg/mL)

p-value

(A)

IL-7

0.94

88

86

5.00

 < 0.001

IL-13

0.89

100

86

3.00

 < 0.05

VEGF

0.88

100

86

40.00

 < 0.05

IL-6

0.88

63

100

6.50

 < 0.01

(B)

IL-7, IL-6

0.90

63

100

 

 < 0.001

IL-13, IL-7

0.87

86

88

 

 < 0.001

IL-13, IL-6

0.85

63

100

 

 < 0.001

IL-7, VEGF

0.74

86

88

 

 < 0.05

VEGF, IL-6

0.74

63

100

 

 < 0.05

IL-13, VEGF

0.73

86

88

 

ns

(C)

IL-13, VEGF, IL-6

0.88

50

86

 

 < 0.001

IL-13, IL-7, IL-6

0.88

50

86

 

 < 0.001

IL-7, VEGF, IL-6

0.76

75

86

 

 < 0.01

IL-13, IL-7, VEGF

0.74

86

88

 

ns

(D)

IL-13, IL-7, VEGF, IL-6

0.76

84

93

 

 < 0.05

  1. ROC receiver operating characteristic, CD Crohn’s disease, UC ulcerative colitis, AUC area under the curve, IL interleukin, VEGF vascular endothelial growth factor.