Table 4 Correlation between the endoscopic scores and serum cytokine levels.

From: Serological cytokine signature in paediatric patients with inflammatory bowel disease impacts diagnosis

 

CD (SES-CD)

UC (UCEIS)

Spearman’s r

p-value

Spearman’s r

p-value

Cytokine panel

IFN-γ

 − 0.035

0.946

0.396

0.383

IL-1β

0.227

0.591

0.558

0.204

IL-2

0.319

0.438

0.631

0.141

IL-4

0.383

0.345

0.558

0.204

IL-6

 − 0.179

0.675

0.378

0.406

IL-10

 − 0.071

0.871

0.684

0.1

IL-13

 − 0.203

0.63

0.792

 < 0.05

TNF-α

0.538

0.178

0.451

0.318

IL-1ra

0.371

0.363

0.378

0.406

IL-5

0.455

0.258

0.558

0.204

IL-7

0.347

0.399

0.774

 < 0.05

IL-9

0.203

0.63

0.486

0.277

IL-12

 − 0.072

0.872

0.414

0.359

IL-15

 − 0.274

0.511

0.272

0.548

IL-17

0.503

0.209

0.631

0.141

Chemokine panel

IL-8

 − 0.071

0.871

0.541

0.221

Eotaxin

0.467

0.247

 − 0.018

0.985

IP-10

0.263

0.523

0.072

0.883

MCP-1

 − 0.131

0.756

0.846

 < 0.05

MIP-1α

0.395

0.339

0.054

0.919

MIP-1β

0.215

0.609

0.505

0.257

Growth factors

G-CSF

 − 0.012

0.988

0.684

0.1

GM-CSF

 − 0.108

0.808

0.738

0.066

VEGF

 − 0.574

0.143

0.792

 < 0.05

FGF-basic

0.119

0.779

0.576

0.187

  1. CD Crohn’s disease, SES-CD simple endoscopic score for CD, UC ulcerative colitis, UCEIS ulcerative colitis endoscopic index of severity, IFN interferon, IL interleukin, TNF tumour necrosis factor, ra receptor antagonist, IP-10 IFN-γ-induced protein 10, MCP monocyte chemoattractant protein, MIP macrophage inflammatory protein, G-CSF granulocyte-colony-stimulating factor, GM-CSF granulocyte–macrophage colony-stimulating factor, VEGF vascular endothelial growth factor, FGF fibroblast growth factor.
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