Table 1 Details of 7 classes of SET domain proteins and the corresponding genes in Arabidopsis thaliana.
From: Identification and characterization of SET domain family genes in bread wheat (Triticum aestivum L.)
Class of SET protein; methylation site | OG* | Genes in OG* | Domains present | Function |
|---|---|---|---|---|
I. Enhancer of Zeste [E(z)] homologs; H3K27 | 1 | MEA (SDG5) | CXC (cysteine-rich region), SET | Repress homeotic gene expression |
2 | CLF (SDG1) | |||
3 | SWN (SDG10) | |||
II. ASH1 homologs and related proteins (OGs based on position of SET domain); H3K36 | 1 | ASHH3 (SDG7), ASHH4 (SDG24) | AWS, SET, Post-SET | Positive regulator of homeotic gene expression |
2 | ASHR3 (SDG4) | PHD, AWS, SET, Post-SET | ||
3 | ASHH1 (SDG26) | Zf, AWS, SET, Post-SET | ||
4 | ASHH2 (SDG8) | AWS, SET, Post-SET, CW | ||
III. Trithorax homologs and related proteins ; H3K4 | 1 | ATX1 (SDG27), ATX2 (SDG30) | SET, Post-SET, PWWP, FYRN, FYRC, PHD | Positive regulator of homeotic gene expression |
2 | ATX3 (SDG14), ATX4 (SDG16), ATX5 (SDG29) | SET, Post-SET, PWWP, PHD | ||
3 | ATXR3 (SDG2) | SET, Post-SET | ||
4 | ATXR7 (SDG25) | SET, Post-SET | ||
IV. Proteins with a SET and a PHD domain; H3K4 | 1 | ATXR5 (SDG15), ATXR6 (SDG34) | SET, PHD | Cell cycle regulation or DNA replication |
V. Suppressor of variegation [Su(var)] homologs (SUVH) and relatives (SUVR); H3K9 | 1 | SUVH1 (SDG32), SUVH3 (SDG19), SUVH7 (SDG17), SUVH8 (SDG21) | YDG, Pre-SET, SET, Post-SET | Heterochromatin formation and DNA methylation in locus specific manner |
2 | SUVH4 (SDG33), SUVH6 (SDG23) | YDG, Pre-SET, SET, Post-SET | ||
3 | SUVH2 (SDG3), SUVH9 (SDG22) | YDG, Pre-SET, SET, Post-SET | ||
4 | SUVR3 (SDG20) | Pre-SET, SET, Post-SET | ||
5 | SUVH5 (SDG9) | YDG, Pre-SET, SET, Post-SET | ||
6 | SUVR1 (SDG13), SUVR2 (SDG18), SUVR4 (SDG31) | WIYLD, Pre-SET, SET, Post-SET | ||
7 | SUVR5 (SDG6) | Pre-SET, SET, Post-SET | ||
VI. proteins with an interrupted SET domain; H3K36 | NA | ASHR1 (SDG37), ASHR2 (SDG39), ATXR1 (SDG35), ATXR2 (SDG36), ATXR4 (SDG38) | SET domain of ASHR1 interrupted by Zf-MYND domain | Restricts cell cycle progression |
VII. RBCMT and other SET-related proteins; methylation of non-histone proteins | NA | SDG40, two anonymous proteins (corresponding to At2g18850 and At5g14260) and five uncharacterized proteins | SET domain | Carbon fixation |
