Figure 3 | Scientific Reports

Figure 3

From: Towards personalized induction therapy for esophageal adenocarcinoma: organoids derived from endoscopic biopsy recapitulate the pre-treatment tumor

Figure 3

EDO can be used to test patient specific treatments. (A) Copy number variation on chromosome 17 for patient 74. ERBB2 amplification is highlighted for both endoscopy and EDO. (B) Representative picture of HER2 IHC on endoscopy and EDO. (C) Mubritinib dose response for all five EDOs. (D) Bright light microscopy pictures of EDO 74 and 92 treated with and without Mubritinib (100 nM) for 7 days.

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