Table 1 Proteins with changed abundance in ΔessC and ΔesxC mutants relative to the WT USA300 JE2.

Signal transduction systems

Q2FK09

 − 3.0

4.90E−13

 − 3.1

4.90E−13

Sensory transduction protein LytR

Q2FH23

 − 2.9

0.002527

 − 2.1

0.026184

Response regulator ArlR

Membrane proteins

A0A0H2XF42

3.0

1.75E−10

0

1

Cytochrome D ubiquinol oxidase, subunit I

A0A0H2XDZ5

1.7

1.68E−05

0

1

Uncharacterized membrane protein

A0A0H2XFJ8

2.0

0.001077

0.5

0.883953

Uracil permease

A0A0H2XGW7

2.7

0.005757

2.5

0.010784

Putative lipoprotein

A0A0H2XIA9

1.0

0.006115

0

1

Protein translocase subunit SecY

Q2FIN2

1.6

0.029451

0.5

0.970614

Prolipoprotein diacylglyceryl transferase LGT

A0A0H2XKD9

2.0

0.038093

1.8

0.070347

Staphylococcal respiratory response protein SrrB

A0A0H2XFE1

3.4

0.039814

1.1

0.970614

Peptidase

A0A0H2XJV8

2.0

0.04444

1.5

0.231285

Cyclic-di-AMP phosphodiesterase

A0A0H2XGF4

3.0

0.044681

0.9

0.986458

Sodium:dicarboxylate symporter family protein

A0A0H2XHV2

2.5

0.049168

2.4

0.070182

Glycine betaine transporter OpuD

Stress response

A0A0H2XKH6

2.2

5.80E−05

2.5

1.07E−05

Universal stress protein family

A0A0H2XIZ0

0.0

1

 − 3.4

1. 06E−10

OsmC/Ohr family protein

DNA repair

Q2FHE2

 − 2.3

1.79E−08

 − 2.3

1.19E-08

DNA mismatch repair protein MutL

A0A0H2XI63

 − 2.0

0.004036

 − 2.0

0.004036

DNA repair protein RadA

A0A0H2XHT1

 − 0.3

0.708343

 − 1.9

0.008379

Formamidopyrimidine-DNA glycosylase MutM

Oxidation–reduction process

A0A0H2XJ90

1.1

0.038093

1.0

0.088334

D-isomer specific 2-hydroxyacid dehydrogenase family protein

A0A0H2XHE0

2.4

0.039099

 − 0.1

1

Thiol-disulphide oxidoreductase, DCC family protein

A0A0H2XGR9

0.0

1

1.4

8.89E-08

Oxidoreductase, Gfo/Idh/MocA family

A0A0H2XK08

1.0

0.406975

2.9

0.00791

Oxidoreductase, short chain dehydrogenase/reductase family

A0A0H2XFZ3

 − 0.8

0.404225

2.1

0.016405

Nitroreductase family protein

Hydrolases

A0A0H2XE49

2.9

1.07E−06

2.9

5.99E−07

Amidohydrolase

Q2FES9

 − 2.7

0.003385

 − 0.3

1

Uncharacterized hydrolase

A0A0H2XFF2

 − 0.8

0.016697

 − 0.5

0.157809

Peptidase, U32 family

A0A0H2XJH8

0.0

1

2.8

1.06E−10

Peptidase M20 domain-containing protein 2

A0A0H2XJ54

0.0

1

2.0

0.000949

Hydrolase (HAD superfamily)

Q2FEG2

 − 0.2

0.854748

 − 2.9

0.004615

Formimidoylglutamase

Metabolism

A0A0H2XGU2

 − 1.6

4.99E−06

 − 0.1

1

Pseudouridine synthase

A0A0H2XK15

2.8

0.004424

0.9

0.777138

1-phosphatidylinositol phosphodiesterase

Q2FEK2

 − 1.6

0.038093

 − 0.3

1

Urease accessory protein UreE

Q2FI05

1.1

0.038093

0.0

1

Bifunctional purine biosynthesis protein PurH

Q2FIL2

2.9

0.038093

0.8

0.970614

SsrA-binding protein

A0A0H2XII6

1.8

0.038093

1.5

0.088334

Orn/Lys/Arg decarboxylase

A0A0H2XJR8

 − 0.9

0.04444

 − 0.5

0.61246

RNA methyltransferase, RsmD family

A0A0H2XKG7

0.0

1

1.4

8.18E−08

Aspartokinase

Cell wall composition

A0A0H2XJQ4

 − 4.0

4.92E−11

 − 4.0

3.28E−11

Acetyltransferase, GNAT family

A0A0H2XKG3

 − 2.3

0.001238

 − 1.7

0.016405

Fibronectin binding protein B

A0A0H2XJC8

 − 2.3

0.009779

 − 3.0

0.000819

Phi77 ORF017-like protein (Toxin MazF)

Q2FE03

0.0

1

2.6

1.18E−12

Fibronectin-binding protein A

Nucleotide binding

A0A0H2XHY5

 − 2.3

8.58E−06

 − 2.3

6.01E−06

ATP-grasp domain protein

A0A0H2XFA5

3.3

0.014259

3.5

0.008379

Putative GTP-binding YqeH protein

Uncharacterised proteins

A0A0H2XGJ8

2.2

0.000372

2.4

9.41E−05

Uncharacterized protein

A0A0H2XE09

2.1

0.008231

1.9

0.016405

Ybbr-like uncharacterized protein

Q2FFI4

3.4

0.020136

0.9

0.970614

UPF0316 membrane protein

A0A0H2XG24

1.1

0.022345

0.8

0.088334

Uncharacterized protein