Figure 1

Schematic representation of the experimental design. Timeline for surgical castration, vehicle, TES 2.5 mg/kg or TES 7.5 mg/kg continuous administration and sacrifice of C57BL/6 mice. Plasma and tissue analysis at each time point, is also indicated. 5-HT, serotonin; TES, testosterone. (Fig. 1 was constructed by Barbosa-Martins, J.).