Table 3 Metabolite variation observed in the models established within the training set.

From: Blood biomarkers indicate that the preclinical stages of Alzheimer's disease present overlapping molecular features

Model 1

Model 2

CN–ADa

CN–MCIa

CN

Metabolite

AD

CN

Metabolite

MCI

 

Gln

↑

 

Glc, Gln, Ile, Leu, Tyr, Val

↑

↑

Ace, Cho, Ile, Leu, Val

 

↑

Ace, Lac, Glu, His, Lys

 

Model 3

Model 4

SMD–ADa

MCI–ADa

SMD

Metabolite

AD

MCI

Metabolite

AD

 

Ace, Cho, MeOH, Pc/Gpc

↑

 

Glc, Glyceryl lipids, Lac

↑

↑

uFA, sFA, Glc

 

↑

Ala, Ile, Leu, Val

 
  1. aUpward arrows indicate a higher concentration of the metabolites in the corresponding class with respect to the other one. Metabolites in bold present VIP > 1 and |pcorr|≥ ± 0.6. Ace, acetate; Ala, alanine; Cho, choline; Glc, glucose; Gln, glutamine; Glu, glutamate; Gpc, glycerolphosphocholine; His, histidine; Ile, isoleucine; Lac, lactate; Leu, leucine; Lys, lysine; MeOH, methanol; Pc, phosphocholine; sFA, saturated fatty acids; Tyr, tyrosine; uFA, unsaturated fatty acids; Val, valine.
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