Figure 1
From: Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis
Surface and intracardiac electrocardiograms (ECG) of NO2-OA versus vehicle treated mice. (A) Representative images of ECG before induction of myocardial ischemia (Baseline; left panel), 20 min after ischemia induction without right ventricular stimulation (AMI; middle panel) and after right ventricular stimulation (STIM; right panel) with appearance of ventricular tachycardias (VT) in NO2-OA- or vehicle treated mice. Scale bar = 200 ms. (B) Probability of VT in sham versus LAD-ligated mice (AMI) with and without NO2-OA treatment (AMI vehicle: 11.2 ± 3.1% vs. AMI NO2-OA: 3.6 ± 2.3; n = 8/7). (C) Number of VT episodes (AMI vehicle: 5.4 ± 1.5 vs. AMI NO2-OA: 1.7 ± 1.1; n = 8/7) and (D) Total time of VT episodes in sham versus AMI mice with and without NO2-OA treatment (AMI vehicle: 3.2 ± 2.4 s vs. AMI NO2-OA: 0.6 ± 0.4 s; n = 8/7). Graphs show Mean ± SEM. Brackets indicate Mean ± SD. *** P < 0.001.
