Figure 1

Lasso configuration of \(L_2\) type studied with minimal surface and GLN methods. Left panel: Schematic picture, with a disulfide bridge (in orange) closing a covalent loop, and a minimal surface (in gray) which spans the loop and is pierced twice by the tail. Middle panel: A cartoon representation of a hydrolase protein (PDB code 5uiw, chain B), with disulfide bridge between amino acids 10 and 34. It is of \(L_2\) type, with minimal surface (in gray) and tails coloured according to the GLN values between their segments and whole loop. Right panel: The topological fingerprint of a lasso based on the GLN matrix for the same protein. Each cell of the matrix corresponds to the GLN value between the disulfide loop and the specific subchain of the tail (here C terminus, the longer one), where the id of the first residue is on the x-axis and the id of the last residue is on the y-axis, thus the left bottom corner corresponds to the whole tail. The C-tail in the middle panel is colored according to the diagonal of the matrix.