Figure 5 | Scientific Reports

Figure 5

From: Hemoglobin stimulates vigorous growth of Streptococcus pneumoniae and shapes the pathogen's global transcriptome

Figure 5

Hemoglobin activates Spn genes vital for host colonization. The relative expression of genes involved in metabolism, nutrient uptake, virulence, or regulation, at 1 h and 2 h post hemoglobin addition (Y-axis) is plotted for D39 genes (X-axis). (A) Up-regulated genes. Stripes indicate involvement in nasopharyngeal colonization. (B) Down-regulated genes. (C) Dot plot representation of gene expression levels depicting average normalized RNA-seq read counts (Y-axis) for cells with 1 h post-hemoglobin treatment is plotted for D39 genes (X-axis). Genes encoding heme/hemoglobin binding (red) or virulence factors (blue) are highlighted.

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